CIPROFLOXACIN
CIPROFLOXACIN or
Cipro, is an effective treatment prescribed for individuals who have been exposed to the disease known
as inhalational Anthrax. It is one of three drugs including Doxycycline and Penicillin used to fight
inhalational Anthrax, however it is not recommended for use by everyone. The following information explains
all forms of the Anthrax disease, who is eligible to take Ciprofloxacin and Doxycycline, potential
side effects of each drug and the appropriate dosages.
CIPROFLOXACIN is an antibiotic used to fight bacteria in the body and falls in a class of drugs called
fluoroquinolones. First approved for use in the United States in 1987, it has since been used to treat 250 million
patients worldwide. It is now approved for 14 indications including serious infections of the lower respiratory tract,
intra-abdominal, typhoid fever, bone and joint infections and inhalational anthrax.
CIPROFLOXACIN given as an oral tablet is rapidly and well absorbed from the gastrointestinal tract after oral
administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass
metabolism.
GENERIC CIPRO functions the same way as Ciprofloxacin, but at a lower cost. To learn more about
generic Ciprofloxacin, please follow the information we have provided below.
 Indications
CIPROFLOXACIN is indicated for the treatment of infections caused by susceptible strains of the
designated microorganisms in the conditions listed below.
Acute Sinusitis: Caused by Haemophilus influenzae, Streptococcus pneumoniae or Moraxella catarrhalis.
Lower Respiratory Tract Infections: Caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter
cloacae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae, or
Streptococcus pneumoniae. Also, Moraxella catarrhalis for the treatment of acute exacerbations of chronic
bronchitis.
NOTE: Although effective in clinical trials, generic Cipro is not a drug of first choice in the
treatment of presumed or confirmed pneumonia secondary to Streptococcus pneumoniae.
Urinary Tract Infections: Caused by Escherichia coli, Kiebsiella pneumoniae, Enterobacter cloacae, Serratia
marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter
freundii, Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus saprophyticus, or
Enterococcus faecalis.
Acute Uncomplicated Cystitis in Females: Caused by Escherichia coli or Staphylococcus saprophyticus.
Skin and Skin Structure Infections: Caused by Escherchia coli, Kiebsiella pneumoniae, Enterobacter cloacae,
Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii,
Pseudomonas aeruginosa, Staphylococcus aureus (methicillin susceptible), Staphylococcus epidermidis, or
Streptococcus pyogenes.
Bone and Joint Infections: Caused by Enterobacter cloacae, Serratia marcescens, or Pseudomonas aeruginosa.
Infectious Diarrhea: Caused by Escherichia coli (entarotoxigenic strains), Campylobacter jejuni, Shigella boydii,
Shigella dysenteriae, Shigella flexneri or Shigella sonnei when antibacterial therapy is indicated.
Typhoid Fever (Enteric Fever): Caused by Salmonella typhi.
NOTE: The efficacy of generic Cipro in the eradication of the chronic typhoid carrier state has not been
demonstrated.
Uncomplicated Cervical and Urethral Gonorrhea: Due to Neisseria gonorrhoeae.
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Contraindications
Do not take antacids that contain magnesium or aluminum (such as Tums or Rolaids); the ulcer medicine sucralfate
(Carafate); or vitamin or mineral supplements that contain iron or zinc for a minimum of 6 hours before or 2 hours
after a dose of generic Cipro. They can decrease the effects of the antibiotic.
Before taking generic Cipro, tell your doctor if you are taking any of the following drugs:
didanosine (Videx, ddI); theophylline (Theo-Dur, Theoliar, Slo-Phyllin, Slo-Bid, Elixophyllin); warfarin (Coumadin);
probenecid (Benemid); insulin or an oral diabetes medication such as glipizide
(Glucotrol), glyburide (Micronase, Diabeta, Glynase), and others; a nonsteroidal anti-inflammatory drug
(NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others) naproxen (Aleve,
Naprosyn, Anaprox) ketoprofen (Orudis KT, Orudis, Oruvail), and others; phenytoin
(Dilantin); or cyclosporine (Neoral, Sandimmune).
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Side effects of Generic Cipro
If you experience any of the following serious side effects, stop taking
generic Cipro immediately and seek emergency medical attention. Allergic reactions such as difficulty breathing,
swelling of the lips, tongue, face or a break out in hives; seizures; confusion or hallucinations; liver damage
(yellowing of the skin or eyes, unusual bleeding or bruising, severe fatigue); muscle or joint pain.
If you experience any of the following less serious side effects, talk to your doctor:
nausea; vomiting; diarrhea; abdominal pain; rash; headache; lightheadedness; drowsiness; ringing of the ears;
restlessness; or increased sensitivity to sunlight.
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Dosage and administration
The recommended adult dose of
generic Cipro for post-exposure inhalational anthrax is 500 milligrams given orally twice a day.
The recommended pediatric dose of generic Cipro (children 12 years of age and older) is 15 mg given orally twice a day.
Treatment with generic Cipro should begin as soon as possible after exposure and be administered for a total of 60 days.
The recommended adult dosage for acute sinusitis is generic Cipro 500-mg every 12 hours.
Lower respiratory tract infections may be treated with generic Cipro 500-mg every 12 hours. For more severe or
complicated infections, a dosage of generic Cipro 750-mg may be given every 12 hours.
Severe/complicated urinary tract infections or urinary tract infections caused by organisms not highly susceptible to
ciprofloxacin may be treated with generic Cipro 500-mg every 12 hours. For other mild/moderate urinary infections,
the usual adult dosage is generic Cipro 250-mg every 12 hours.
In acute uncomplicated cystitis in females, the usual dosage is generic Cipro 100-mg every 12 hours. For acute
uncomplicated cystitis in females, 3 days of treatment is recommended while 7 to 14 days is suggested for other
mild/moderate, severe or complicated urinary tract infections.
The recommended adult dosage for chronic bacterial prostatitis is generic Cipro 500-mg every 12 hours.
The recommended adult dosage for oral sequential therapy of complicated intra-abdominal infections is generic Cipro 500-mg
every 12 hours. (To provide appropriate anaerobic activity, metronidazole should be given according to product labeling.)
Skin and skin structure infections and bone and joint infections may be treated with generic Cipro 500-mg every 12 hours.
For more severe or complicated infections, a dosage of generic Cipro 750-mg may be given every 12 hours.
The recommended adult dosage for infectious diarrhea or typhoid lever is generic Cipro 500-mg every 12 hours. For the
treatment of uncomplicated urethral and cervical gonococcal infections, a single generic Cipro 250-mg dose is recommended.
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